What is the appropriate PaO2 level for VV ECMO oxygenation?

The appropriate partial pressure of oxygen in arterial blood, or PaO2, for patients on venovenous ECMO (VV ECMO) typically falls in the range of 50-60 mmHg. This target is vital for ensuring adequate oxygenation while avoiding potential complications associated with oxygen toxicity that can arise from excessively high oxygen levels. Maintaining a PaO2 within this range indicates that the ECMO is effectively oxygenating the blood and supporting the patient’s cardiopulmonary function.

In clinical practice, achieving a PaO2 too high can lead to oxidative stress and lung injury, which is particularly concerning in patients requiring ECMO support for respiratory failure. Thus, the goal is to balance sufficient oxygen delivery while minimizing such risks. This optimal level also aligns with the physiological tolerance of the human body, promoting effective gas exchange while maintaining organ perfusion and function.